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KMID : 0603820100160040271
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Journal of Experimental & Biomedical Science
2010 Volume.16 No. 4 p.271 ~ p.277
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Biological activities of Solvent Fractions Isolated from Areca catechu L
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Kim Jun-Ho
Oh Hae-Sook
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Abstract
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This study was conducted to investigate the biological activities of Areca catechu L. The antioxidative, fibrinolytic, thrombin inhibitory, and α-glucosidase inhibitory activities of Areca catechu L extracted with hexane, CHCl₃, ethyl acetate, butanol, and water were measured. The water fraction showed the highest extraction yield at 3.65% (w/w). The butanol, CHCl₃, water, and ethyl acetate fractions showed strong antioxidative activities at 81.6%, 87.1%, 88.0%, and 89.5%, respectively. The fibrinolytic activity was strong only in the ethyl acetate fraction at 0.84 plasmin units/ml. The 100-fold dilution of the water fraction had the strongest thrombin inhibitory activity at 59.2%. The 100-fold dilution of butanol fraction displayed the strongest α-glucosidase inhibitory activity at 88.6%. In conclusion, the extracts of Areca catechu L hold promise for use in the development of biofunctional foods to prevent cardiovascular diseases.
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KEYWORD
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Antioxidative activity, Areca catechu L, Fibrinolytic activity, α-Glucosidase inhibitory activity, Thrombin inhibitory activity
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